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T7426 |
ALSTERPAULLONE
|
|
Apoptosis
,
GSK-3
,
CDK
|
|
Alsterpaullone is a Cyclin-Dependent Kinase Inhibitor, Mediated Toxicity in HeLa Cells Through Apoptosis-Inducing Effec |
|
T10096L |
Voruciclib
|
|
CDK
|
|
Voruciclib is an orally active and selective CDK inhibitor (Ki: 0.626 nM-9.1 nM). Voruciclib represses the expression of MCL-1 in multiple models of diffuse large B-cell lymphoma. Voruciclib effectively blocks CDK9, the ... |
|
T2028 |
NG 52
|
NG52,NG-52,Compound 52 |
CDK
|
|
NG 52 (NG-52) is a cell-permeable, reversible, and ATP-compatible inhibitor of the cell cycle-regulating kinase Cdc28p and the related Pho85p kinase. |
|
T7167 |
Purvalanol B
|
NG 95 |
CDK
,
Parasite
|
|
Purvalanol B (NG 95) is a CDK inhibitor that inhibits Cdk2/cyclin A, Cdk2/cyclin E, Cdk5/p35, and Cdk2/cyclin B (IC50s = 6, 9, 6, and 6 nM, respectively) |
|
T2059 |
Purvalanol A
|
NG-60 |
Apoptosis
,
CDK
,
Autophagy
|
|
Purvalanol A (NG-60) is an effective and cell-permeable CDK inhibitor with IC50 of 70/4/35/850 nM for cdk2-cyclin A/B/E, and cdk4-cyclin D1, respectively. |
|
T2095 |
Seliciclib
|
Roscovitine,R-roscovitine,CYC202 |
CDK
|
|
Seliciclib (Roscovitine) is a potent inhibitor of Cdk2/cyclin E (IC50: 0.1 μM). It also inhibits Cdk7/cyclin H, Cdk5/p35, and Cdc2/cyclin B (IC50s: 0.49/0.16/0.65 μM). |
|
T14914 |
Cdk1/2 Inhibitor III
|
|
CDK
|
|
Cdk1/2 Inhibitor III is a selective Cdk1/2 inhibitor with an IC50 value of 2.1 μM against CDK1/cyclin B. |
|
T14916 |
CDK2-IN-4
|
|
CDK
|
|
CDK2-IN-4 is a potent and selective inhibitor of CDK2 with an IC50 of 44 nM for CDK2/cyclin A. It shows 2,000-fold selectivity over CDK1/cyclin B with IC50 of 86 uM. |
|
T5200 |
Indirubin-3'-monoxime
|
Indirubin-3'-oxime |
GSK-3
,
Lipoxygenase
,
CDK
|
|
Indirubin-3'-monoxime (Indirubin-3'-oxime) is a potent inhibitor of GSK3β (IC50: 22 nM) and also inhibits CDKs ( (IC50s: 100/180/250 nM for Cdk5/p35, Cdk1/cyclin B, Cdk2/cyclin E). |
|
T69188 |
Aloisine B
|
AloisineB |
GSK-3
,
CDK
|
|
Aloisine B (AloisineB) inhibited cyclin-dependent kinase and glycogen synthase kinase with IC50 values of 0.85 µM and 0.75 µM, respectively. Aloisine B has antiviral activity and can be used to study Alzheimer's, diabete... |
|
T6787 |
BIO-acetoxime
|
BIA,GSK-3 Inhibitor X |
Apoptosis
,
GSK-3
,
HSV
|
|
BIO-acetoxime (GSK-3 Inhibitor X) is a potent dual GSK3α/β inhibitor with IC50 of 10 nM, >240-fold selectivity over CDK5/p25, CDK2/cyclin A and CDK1/cyclin B. |
|
T22260 |
Aminopurvalanol A
|
|
CDK
|
|
Aminopurvalanol A is a competitive, selective and cell-permeable inhibitor of cyclin-dependent kinase (CDK) that potently inhibits Cyclin A/cdk2, Cyclin B/cdk1, Cyclin E/cdk2, and P35/cdk5 with IC50 of 33 nM, 33 nM, 28 n... |
|
T6358 |
1-Azakenpaullone
|
azakenpaullone |
GSK-3
|
|
1-Azakenpaullone (azakenpaullone) is a potent and selective GSK-3β inhibitor with IC50 of 18 nM, >100-fold selectivity over CDK1/cyclin B and CDK5/p25. |
|
T15732 |
Ribociclib succinate
|
LEE011 succinate |
CDK
|
|
Ribociclib succinate (LEE011 succinate) is a highly specific CDK4/6 inhibitor (IC50: 10 nM and 39 nM, respectively). It also is over 1,000-fold less potent against the cyclin B/CDK1 complex. |
|
T16359 |
NU6140
|
|
CDK
,
Aurora Kinase
|
|
NU6140 is a selective inhibitor of CDK2-cyclin A (IC50, 0.41 μM). It shows 10- to 36-fold selectivity over other CDKs. NU6140 also effectively inhibits Aurora A and Aurora B (IC50s: 67 and 35 nM, respectively). It also e... |
|
T2679 |
BMS-265246
|
BMS265246 |
CDK
|
|
BMS-265246 is a potent and selective CDK1/2 inhibitor. |
|
T2247 |
KenPaullone
|
9-Bromopaullone,NSC-664704 |
GSK-3
,
CDK
|
|
KenPaullone (9-Bromopaullone), a potent CDK1, CDK2 and CDK5 inhibitor, as new enhancer for iTreg cell differentiation. Kenpaullone promotes iTreg cell differentiation through increased and prolonged transcription of foxp... |
|
T14943 |
CGP60474
|
|
VEGFR
,
CDK
,
PKC
|
|
CGP60474 is an inhibitor of VEGFR-2 (IC50 = 84 nM) and an inhibitor of ATP-competitive PKC. CGP60474 is also a highly potent anti-endotoxemic agent and inhibits cyclin-dependent kinase (CDK) potently. |
|
T6312 |
R547
|
Ro 4584820 |
Apoptosis
,
GSK-3
,
PKA
,
CDK
|
|
R547 (Ro 4584820) is a potent ATP-competitive inhibitor of CDK1/2/4 with Ki of 2 nM/3 nM/1 nM. It is less potent to CDK7 and GSK3α/β, while inactive to other kinases. Phase 1. |
|
T6187 |
TDZD-8
|
GSK-3β Inhibitor I,NP 01139 |
GSK-3
|
|
TDZD-8 (NP 01139) is an inhibitor of GSK-3β, with an IC50 of 2 μM; minimal inhibitory effect observed on CDK1, casein kinase II, PKA and PKC. |
|
T35610 |
2,5-dimethyl Celecoxib
|
|
Apoptosis
,
Wnt/beta-catenin
,
Prostaglandin Receptor
|
|
2,5-dimethyl Celecoxib is a derivative of celecoxib that does not inhibit COX-2 (IC50 = >100 μM).1 It does inhibit microsomal prostaglandin E synthase-1 (mPGES-1) in HeLa cells (IC50 = 15.6 μM) and reduces prostaglandin ... |
|
T11653 |
Indirubin-5-sulfonate
|
|
Others
|
|
Indirubin-5-sulfonate shows inhibitory activity against GSK-3β. Indirubin-5-sulfonate is a cyclin-dependent kinase (CDK) inhibitor, with IC50 values of 55 nM, 35 nM, 150 nM, 300 nM and 65 nM for CDK1/cyclin B, CDK2/cycli... |
|
T27033 |
CKD-712
|
CKD 712,CKD712 |
|
|
CKD-712 is a nuclear factor NF-kappa B inhibitor. CKD-712 suppressed MMP-9, but not MMP-2 and other NF-κB-regulated proteins involved in cancer metastasis such as VEGF. CKD-712 induced cell cycle arrest at G2M phase by s... |
|
T2082 |
CDK4-IN-1
|
|
CDK
|
|
CDK4 inhibitor is a novel and specific CDK4/Cyclin D1 inhibitor with an IC50 of 10 nM; 1500 and 500 fold than CDK1/Cyclin B (IC50>15 uM) and CDK2/Cyclin A (IC50=5.265 uM) respectively. |
|
T24734 |
RP-106
|
RP 106 |
|
|
RP-106 is an ATP-competitive inhibitor of CDK5/p25, CDK1/cyclin B, and GSK-3. |
|
T68555 |
Alsterpaullone, 2-Cyanoethyl
|
|
|
|
Alsterpaullone, 2-Cyanoethyl is a selective dual inhibitor of Cdk1/cyclin B and GSK-3β. |
|
T21377 |
Aloisine A
|
|
|
|
Aloisine A is a potent and selective CDK/GSK-3 inhibitor. IC50 data of Aloisine A: Cdk1/cyclin B (IC50: 150nM), Cdk2/cyclin A (IC50: 120nM), Cdk2/cyclin E (IC50: 400nM), Cdk5/p25 (IC50: 200nM), Cdk5/p35 (IC50: 160nM), GS... |
|
T13454 |
(S)-Purvalanol B
|
(S)-NG 95 |
BCL
|
|
(S)-Purvalanol B is the S enantiomer of Purvalanol B. Purvalanol B is an inhibitor of cyclin-dependent kinase(CDK) . |
|
T61890 |
(E/Z)-BIO-acetoxime
|
|
|
|
(E/Z) - BIO-acetoxime is effective and selective GSK-3 α/β Inhibitors. For GSK-3 α/β, CDK5/p25, CDK2/cyclin A and CDK1/cyclin B, IC50 are 10nM, 2.4 μM, 4.3 μ M, 63 μ M, respectively。 |
|
T21950 |
K 00546
|
|
|
|
K00546, a potent inhibitor of both cyclin-dependent kinase (CDK1 and CDK2) and CDC2-like kinase (CLK1 and CLK3), demonstrates high specificity with IC50s of 0.6 nM and 0.5 nM for CDK1/cyclin B and CDK2/cyclin A, respecti... |
|
T15730 |
Ribociclib hydrochloride
|
LEE011 hydrochloride |
CDK
|
|
|
|
T10172 |
5-Iodo-indirubin-3'-monoxime
|
|
GSK-3
,
CDK
|
|
5-Iodo-indirubin-3'-monoxime is a potent GSK-3β, CDK5/P25 and CDK1/cyclin B inhibitor, competing with ATP for binding to the catalytic site of the kinase (IC50s: 9, 20 and 25 nM). |
|
T15731 |
Ribociclib succinate hydrate
|
LEE011 succinate hydrate |
CDK
|
|
|
|
T10436L |
AZD4573 HCl (2057509-72-3 free base)
|
AZD4573 hydrochloride,AZD4573,AZD4573 HCl,AZD-4573,AZD 4573 |
|
|
AZD-4573 is a selective and short-acting inhibitor of the serine/threonine cyclin-dependent kinase 9, the catalytic subunit of the RNA polymerase II elongation factor positive transcription elongation factor b. It also h... |
|
T40546 |
3-Methylthienyl-carbonyl-JNJ-7706621
|
|
|
|
3-Methylthienyl-carbonyl-JNJ-7706621 is a highly potent and selective inhibitor of cyclin-dependent kinase (CDK). It exhibits impressive IC50 values of 6.4 nM and 2 nM for CDK1/cyclin B and CDK2/cyclin A, respectively. A... |
|
T69091 |
CBP501
|
|
|
|
CBP501 is a peptide with G2 checkpoint-abrogating activity. G2 checkpoint inhibitor CBP501 inhibits multiple serine/threonine kinases, including MAPKAP-K2, C-Tak1, and CHK1, that phosphorylate serine 216 of the dual-spec... |
|
T37065 |
6-Chloro-2-fluoropurine
|
|
|
|
6-Chloro-2-fluoropurine is a heterocyclic building block.1,2It has been used in the synthesis of purine nucleosides that inhibit cyclin-dependent kinases (CDKs)in vitro.16-Chloro-2-fluoropurine has also been used in the ... |
|
T83890 |
Flavokawain 1i
|
Flavokavain 1i |
|
|
Flavokawain 1i, a derivative of chalcones flavokawain A, flavokawain B, and flavokawain C, exhibits anticancer and antiviral properties. At a concentration of 30 µM, it suppresses the growth of gefitinib-resistant H1975 ... |
